CUTTING-EDGE RESEARCH

·Exploring the mysteries of anti-aging
·Researching, developing, reserving, and applying cutting-edge technologies from both domestic and international sources
·Full-chain research on stem cells, immune cells, exosomes, and other related fields

INTRODUCTION TO ZHONGYAN YOUKE

Zhongyan Youke Stem Cell Research Institute
Established based on the scientific research backgrounds of top-tier universities both domestically and internationally, it is a novel cell technology research institution integrating research and development, translation, and application. It has established a full-chain stem cell research platform spanning from basic research, applied research, to practical clinical applications. The institution boasts a cGMP sterile cell laboratory spanning over 2000 square meters, with an overall cleanliness level of 10,000 and local cleanliness level of 100, as well as a cGMP ultra-clean biological sample bank. It has established a comprehensive technical system from cell screening, separation, purification, culture, expansion, to quality control and certification, adhering to international super-class standards. The research institute possesses multiple core technologies such as genetic engineering technology, stem cell technology, immune cell technology, and cell storage. The institute houses three major research centers: anti-aging health, medical aesthetics, and medical breakthroughs. It also boasts a highly educated research and promotion team primarily composed of Ph.D. and Master's degree holders. By utilizing international cutting-edge stem cell technology, it Anti-aging and health enhancement aims to safeguard the health and beauty of the Chinese public.

stem cell

APPLICATION FIELDS OF STEM CELLS FROM TREATING DISEASES TO ANTI-AGING

What is a stem cell? -- The seed of life.
Core definition:

Stem cells are a type of primitive cell with self-renewal and multi-directionaldifferentiation potential. They are the "originating cells" that construct allhuman tissues, serving as a "cell factory" and "repair system" within thebody.With the potential to regenerate various tissues, organs, and the entirehuman body,they are known in the medical community as "universalcells".
The three unique abilities of stem cells: ①self-renewal ②multidirectional differentiation ③homing

application

THE APPLICATION FIELDS OF STEM CELLS
RANGE FROM TREATING DISEASES TO ANTI-AGING

Innovative therapies for intractable diseases

Autoimmune disease: For conditions such as rheumatoid arthritis and systemic lupus erythematosus, the immune system can be restored to normal through immune regulation
Liver disease and diabetes: Promoting liver regeneration and repairing pancreatic islet function bring new hope for the treatment of liver failure and diabetes.

Anti-aging and health enhancement

Cellular Anti-Aging: By infusing young stem cells to replace aging and apoptotic cells, the aging process of tissues and organs can be delayed from the root. Improving function: It helps improve physical function, enhance energy, physical strength, and sleep quality, radiating vitality from within. Restoring appearance: Promoting the regeneration of collagen in the skin, improving skin texture, reducing wrinkles, and achieving facial rejuvenation.

Disease modeling and new drug screening

Using stem cells to cultivate "organoids" to simulate human diseases in vitro, which can be used for pathological research and drug testing, acceleratingthe development of new drugs.

The RYUICHI NISHINAKAMURA team from Kumamoto University published a study in "NATURE COMMUNICATIONS": they established a method for inducing ureteral mesenchymal precursor cells from mouse and human pluripotent stem cells in vitro for the first time, successfully cultivating stem cell-derived ureteral-like spherical organoids. This technology provides crucial support for elucidating the mechanisms of organ development and research on related diseases
REAL CASE

exosome

NK CELL EXOSOMES

The application and advantages of the new generation of natural immunotherapy

What is NK cell exosome?

NK cell exosomes (50-150nm nanovesicles) inherit the natural immune function of NK cells, carry active molecules such as perforin and granzyme, precisely recognize and eliminate abnormal cells, and regulate the immune microenvironment

exterior

THE APPLICATION OF NK CELL
EXOSOMES IN MULTIPLE FIELDS

Direct anti-tumor killing

Multiple studies have shown that NK cell exosomes exhibit significant anti-tumor effects in both in vitro and in vivo experiments. For instance, the research team led by Byeong-Cheol Ahn from the College of Medicine, Kyungpook National University, South Korea, explored the anti-tumor effects of NK cell exosomes against melanoma in vitro and in vivo.
The researchers tested the tumor-suppressing effect of NK cell exosomes in vivo using a mouse model and found that the tumor size in the NK cell exosome-treated group was significantly smaller than that in the control group
Figure 1: NK cell exosomes exert cytotoxic effects on melanoma cells▲
Figure 2: Chemotherapy drugs, non-coding RNAs, photosensitizers, and ferroptosis inducers are designed to be encapsulated in NK-Exos to enhance their anti-tumor efficacy

|| Type 2 diabetes and metabolic syndrome

Research has shown that NK cell exosomes derived from lean mice can alleviate insulin resistance and inflammation in obesity-induced type 2 diabetes mouse models. They significantly improve insulin sensitivity in diabetic mice. Furthermore, exosomes also exhibit a positive effect in promoting diabetic wound healing by regulating processes such as angiogenesis, collagen synthesis, and inflammation inhibition, thereby accelerating the wound healing process.
Precision delivery carrier for chemotherapy drugs Enhance immune response

stem cell

APPLICATION OF PLANT EXOSOMES

Natural active carrier precise efficacy matrix reshaping skin

What is plant exosome

Plant exosomes are nanoscale vesicles (50-150nm in diameter) secreted by plant cells, carrying plant active molecules and capable of penetrating the skin barrier to precisely deliver repair signals

The revitalizing power of the “King of Herb

Based on exosome technology, researchers have successfully extracted "ginseng exosome vesicles" from the juice of ginseng root hairs.
These tiny vesicles are loaded with ginseng active essence, capable of efficiently penetrating the skin barrier and delivering effective ingredients to target cells, exerting a repairing effect.

Beauty and skincare

Brightening and spot-fading: Inhibiting tyrosinase to reduce the activity of melanocytes, minimize the appearance of pigmentation spots, and evenly brighten the skin tone.
Anti-wrinkle and firming: Contains ginsenosides and peptides, which promote collagen synthesis and enhance skin elasticity.
Moisturizing and repairing: Ginseng polysaccharides provide long-lasting moisturization, repair the skin barrier, and alleviate dryness and sensitivity

Tissue repair

Accelerate wound healing: Regulate inflammatory factors, reduce redness and swelling, promote cell migration, accelerate wound healing, and reduce scarring. Revitalize damaged cells: Activate the cell self-repair mechanism, improving issues such as acne scars and sensitivity. Anti-inflammatory and antioxidant: Alleviate inflammatory reactions triggered by external stimuli, neutralize free radicals, and delay aging. Cell communication function: Act as a "postman" of signal molecules, participating in gene expression regulation and assisting in maintaining skin health and homeostasis.